Classification of Proteins (CLAP)

CLAP is a web server for automatic classification of protein sequences. It uses an alignment free approach to compute local similarities among sequences [Martin J et al., 2010]. This method is particularly useful for comparing multi-domain protein sequences which are difficult to align [Bhaskara RM et al., 2014]. CLAP can handle multiple sequences of varied lengths, resulting in clusters with high functional and domain architectural similarities.

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When refering to CLAP, please reference the following papers

1. Classification of protein kinases on the basis of both kinase and non-kinase regions. Martin J, Anamika K, Srinivasan N. PLoS One. 2010 Sep 15;5(9):e12460. doi: 10.1371/journal.pone.0012460. PMID: 20856812

2. The relationship between classification of multi-domain proteins using an alignment-free approach and their functions: a case study with immunoglobulins. Bhaskara RM, Mehrotra P, Rakshambikai R, Gnanavel M, Martin J, Srinivasan N. Mol Biosyst. 2014 Apr 1;10(5):1082-93. doi: 10.1039/c3mb70443b. PMID: 24572770

3. CLAP: A web-server for automatic classification of proteins with special reference to multi-domain proteins. Gnanavel M, Mehrotra P, Rakshambikai R, Martin J, Srinivasan N, Bhaskara RMBMC Bioinformatics. 2014 Oct 4, 15:343. doi: 10.1186/1471-2105-15-343.

CLAP was last updated on 26 September, 2014.